In 1950, 32 college-trained Black women sought to perpetuate the traditions and ideals of Alpha Kappa Alpha Sorority, Inc. Their vision to improve the quality of life for the residents of the Queens community led them to work toward forming a local chapter of AKA. The new chapter, Epsilon Pi Omega, was chartered on May 13, 1950 at the Springfield Gardens United Methodist Church in Queens, New York.

Over the years, the chapter's membership has increased from the original 32 charter members to over 200 members (as of May 2021). In keeping with the sorority's tradition of promoting academic excellence and enriching the lives college women, the chapter over the years, also chartered two undergraduate chapters, Nu Mu and Nu Psi. Today, Epsilon Pi Omega remains the proud sponsoring chapter of Nu Mu Chapter, seated at St. John’s University, Queens College/CUNY and York College/CUNY.

Since its inception, Epsilon Pi Omega has collaborated with a variety of governmental and community organizations to address the needs of local residents. The chapter implements innovative programs and activities that focus on Education, Economic Empowerment, Health, the Arts and the Black Family, and like the Sorority as a whole, EPiO supports and raises awareness of HBCUs (Historically Black Colleges & Universities).

Epsilon Pi Omega Chapter is committed to sisterhood, leadership and service. This commitment is evident in the chapter’s acknowledgment of local scholars and talents; efforts to educate and mobilize the community towards economic empowerment; and the willingness to work for social and political change. EPiO collaborates with local organizations whenever possible to implement programs and service that will enhance the lives of African-American families.